![]() Syndecan-1 shedding is mediated by matrix metalloproteinase-9 (MMP-9) and counteracted by tissue inhibitor of metalloproteinases (TIMP)-1. ![]() EG impairment can play a role in pathogenesis of vascular disease, and one of its characteristics is shedding of syndecan-1 from endothelial cells. The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet. However, you should be able to temporary hide the Widows cursor by doing the following:Ģ.Gia Deyab, Formal analysis, Investigation, Software, Validation, Writing – original draft, Writing – review & editing, # 1, * Trine Marita Reine, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft, Writing – review & editing, # 2, 3, 4 Tram Thu Vuong, Validation, Writing – review & editing, 5, ‡ Trond Jenssen, Validation, Writing – review & editing, 2, 6, ‡ Gunnbjørg Hjeltnes, Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing, 7, ‡ Stefan Agewall, Validation, Writing – review & editing, 8, 9, ‡ Knut Mikkelsen, Conceptualization, Methodology, Validation, Writing – review & editing, 10, ‡ Øystein Førre, Validation, Writing – review & editing, 6, ‡ Morten Wang Fagerland, Formal analysis, Investigation, Validation, Writing – review & editing, # 11 Svein Olav Kolset, Formal analysis, Project administration, Supervision, Validation, Writing – review & editing, # 4 and Ivana Hollan, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing # 12, 13 Unfortunately there is a bug with the cursor which we are currently looking into. I normally wait for games to show up in a sale, but this one was a insta-buy and I don't regret it one bit. The third dimension really adds to the gameplay. Using Windows 7 圆4, GeForce GTX 670 with latest driver, Trine 64-bit, max. However this effect does not show on screenshots. ) When playing with a Xbox 360 controller the Windows mouse cursor is still visible. When playing with k+m there are two mouse cursors next to each other (one from Trine the other from Windows), Moving it around feels like they are magnetically attached to each other. Originally posted by stellardome:Hello there, I keep seeing the Windows mouse cursor ingame. This has improved things a little bit, but performance is far from ideal. There was another link in that thread that suggested I turned off ambientocclusioncull (set to false). Will there be a patch for this, I'm sure I can't be the only one? Any suggestions? ( Apart from getting a new machine :P ) was little topic about I've tried turning everything off and reducing the resolution to such an extent that now I'm sure it's not my graphics capabilities.Īs I say, even with my ageing specs, I should be able to run this game sufficiently to play it through, but the framerate & stuttering really is terrible.Įven the dialogue cuts out during the load screens. I can also run most games made on the Unreal engine, like Batman Arkham Asylum & Arkham City, up to DX10 without any hitches at all.īut at present Trine 3 is completely unplayable due to stutter, lag and really shoddy framerates. ![]() Originally posted by Skirmish:Ok, my specs are getting a bit old now, but I can run both Trine 1 & 2 at full screen resolution (1920x1200) no problem. :) The videos are for the Trine Enchanted Edition Editor, but all three Trine editors are very similar, so the videos will be a great help with all of them.
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